Following Macroscopic type of Gastric Carcinoma is most common and has favorable prognosis:
A. Intestinal type
B. Diffuse type
C. Mixed type
D. Infiltrative type
Answer: A (S)
Gastric cancer is the fifth most common type of cancer worldwide
Lauren classification of gastric adenocarcinoma
- Intestinal type gastric carcinoma
- Typically localized
- Polypoid, glandular formation
- Similar to an ulcerative lesion with clear raised margins
- Commonly located on the lesser curvature
- Diffuse type gastric carcinoma
- No clear border
- Spreads earlier in the course of disease
- Infiltrative growth
- Diffuse spread in the gastric wall
- Linitis plastica: gastric wall thickening and leather bottle appearance
- Composed of signet ring cells: round cells filled with mucin, with a flat nucleus in the cell periphery
- Associated with E-cadherin mutation
- Intermediate type (the least common type): should be treated as the diffuse type, as the extent of tumor infiltration is difficult to assess
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