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🦷 Parotid Gland – Clinical Overview


Benign Neoplasms

  • 80% of all salivary gland tumours arise in the parotid gland

  • Of these, ~80% are benign

  • Growth rate ≠ malignancy: rapid growth doesn't always imply malignancy

  • Facial nerve involvement = red flag for malignancy

  • Benign tumors are more common in women (except Warthin's)

  • Median age: 5th decade


🧪 Benign Tumour Types

Tumour Features
Pleomorphic adenoma (benign mixed tumour) Most common (~80%). Involves epithelial + myoepithelial cells. Lobulated, slow-growing, not well-encapsulated. Risk of malignant transformation (2–10%) and recurrence if capsule is violated.
Warthin tumour 2nd most common benign tumour (5%). Occurs in older males, often bilateral or multicentric. Cystic with lymphoid tissue. Rare malignant change.
Monomorphic adenoma <5% of tumours. Single cell type. Includes oncocytoma, basal cell adenoma, canalicular adenoma, myoepithelioma. Slow-growing.
Haemangioma Commonest parotid tumour in infants (<1 year). Highly vascular. May regress spontaneously. Rarely becomes malignant.

🔥 Malignant Tumours of the Parotid

Type Features
Mucoepidermoid carcinoma Most common parotid malignancy (30%). Low-grade types less aggressive.
Adenoid cystic carcinoma Perineural invasion with skip lesions. High risk of visceral metastasis. 5-year survival: ~35%.
Carcinoma ex-pleomorphic adenoma Arises from long-standing pleomorphic adenoma.
Acinic cell carcinoma Intermediate malignancy. Possible perineural spread. 5-year survival: ~80%.
Adenocarcinoma Arises from secretory units. Risk of nodal + distant spread. Prognosis depends on stage.
Lymphoma May occur with Warthin’s tumours. Large, rubbery mass. Diagnosis via nodal biopsy. Treated medically (chemo ± radiotherapy).

🧬 Diagnostic Workup

  • Plain X-ray: rule out stones

  • Sialography: ductal anatomy

  • FNAC: essential for diagnosis

  • CT/MRI: for malignancy assessment

  • Superficial parotidectomy: diagnostic + therapeutic for most benign lesions

  • Malignancy → formal resection (avoid excisional biopsy)


🩺 Treatment

  • Benign tumorsSuperficial parotidectomy

  • Malignant tumorsRadical/extended radical parotidectomy

    • Facial nerve resection if involved

    • Neck dissection if nodal spread suspected


🧾 Other Parotid Conditions

Condition Features
HIV-associated lymphoepithelial cysts Bilateral, multicystic swelling. Low malignancy risk. Managed conservatively.
Sjogren syndrome Autoimmune. Bilateral painless enlargement, dry eyes/mouth. Lymphocytic infiltrates. ↑ Lymphoma risk.
Sarcoidosis Parotid involved in ~6%. Usually bilateral, painless, with possible xerostomia. Conservative management if isolated.


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